【摘 要】
：
目的:探讨大鼠变应性鼻炎制模基础致敏阶段,给予CpGDNA(CpG1826)腹腔注射对其鼻黏膜EOTAXIN表达的影响作用。方法:在大鼠变应性鼻炎基础致敏阶段,腹腔注射卵清蛋白和氢氧化铝
【机 构】
：
华中科技大学附属协和医院耳鼻咽喉科,华中科技大学附属协和医院耳鼻咽喉科,华中科技大学附属协和医院耳鼻咽喉科 武汉430022,武汉430022,武汉430022
论文部分内容阅读
目的:探讨大鼠变应性鼻炎制模基础致敏阶段,给予CpGDNA(CpG1826)腹腔注射对其鼻黏膜EOTAXIN表达的影响作用。方法:在大鼠变应性鼻炎基础致敏阶段,腹腔注射卵清蛋白和氢氧化铝佐剂的同时,给予CpGDNA腹腔注射,观察其对模型形成的影响。观测指标包括症状得分、鼻黏膜局部嗜酸粒细胞表达以及鼻黏膜局部EOTAXIN表达情况。结果:CpGDNA应用后,变应性鼻炎模型症状减轻,鼻黏膜局部及骨髓中嗜酸粒细胞减少,鼻黏膜中EOTAXIN表达降低。结论:CpGDNA在基础致敏阶段应用对大鼠变应性鼻炎模型形成具有显著的干扰作用,其对鼻黏膜EOTAXIN表达的抑制可能为其作用机制之一。
Objective: To investigate the effect of intraperitoneal injection of CpG DNA (CpG1826) on the expression of EOTAXIN in rat nasal mucosa during the basic sensitization phase of allergic rhinitis in rats. METHODS: CpG DNA was injected intraperitoneally (ip) to ovalbumin and aluminum hydroxide adjuvant in rats during the basal sensitization phase of allergic rhinitis. The effects of CpG DNA on the model formation were observed. Observations include symptom score, nasal mucosa local eosinophil expression and nasal mucosa local EOTAXIN expression. RESULTS: After CpG DNA was applied, symptoms of allergic rhinitis alleviated, eosinophils in local and bone marrow of nasal mucosa decreased, and expression of EOTAXIN in nasal mucosa decreased. CONCLUSION: CpGDNA has a significant interference on the formation of allergic rhinitis model in rats during the basic sensitization phase. Inhibition of EOTAXIN expression in nasal mucosa may be one of its mechanisms.
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