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用国产厌氧棒状杆菌菌苗治疗5例恶性黑色素瘤,2例为手术后,3例为术后复发才接受治疗。全部患者均用4mg/周经3个月瘤内或皮下注射后,每月4mg维持治疗至今,全部活存。1例活存63月未复发,1例活存61月,第3例完全消退已活存46月,另2例亦活存30月。测定患者巨噬细胞及淋巴细胞对D-6靶细胞细胞毒活性,发现治疗后巨噬细胞及淋巴细胞细胞毒效应均有不同程度提高,脑转移患者细胞毒功能始终低下,提示细胞免疫功能测定对于推测预后可能具有一定意义。
Five cases of malignant melanoma were treated with domestic anaerobic coryneform bacilli, two were treated and three were treated for postoperative recurrence. All patients with 4mg / week after 3 months of intratumoral or subcutaneous injection, monthly maintenance 4mg so far, all alive. One patient survived without recurrence in 63 months, and one patient survived in June. The third patient survived completely in 46 months and the other two patients survived in 30 months. The cytotoxic activity of macrophages and lymphocytes on D-6 target cells was determined and the cytotoxic effects of macrophages and lymphocytes were found to be improved to varying degrees after treatment. The cytotoxicity of patients with brain metastases was always low, suggesting that cellular immune function May have some significance for the prediction of prognosis.