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为探讨抗菌药物致肾脏损害早期监测的方法,对使用无肾毒性(头孢三嗪)、轻度肾毒性(头孢唑啉)、明显肾毒性(庆大霉素)三种不同药物的患者用药前及用药后1周测定其血尿素氮、肌酐、尿β_2-微球蛋白、尿视黄醇结合蛋白、尿微量白蛋白、尿IgG、尿N-乙酰-β-氨基葡萄糖苷酶.结果发现头孢三嗪患者用药前后各项指标均无明显改变;头孢唑啉组者尿系列微量蛋白显著增高时(P<0.01或P<0.05),血尿素氮、肌酐仍无明显改变(P>0,05);庆大霉素组血肌酐轻度上升时,而尿系列微量蛋白成倍增高.提出尿系列微量蛋白的测定对药物肾毒性的早期监测具有一定的临床意义.
To investigate the early detection of renal damage caused by antimicrobial agents, the use of three different drugs, nephrotoxic (cefotaxime), mild nephrotoxic (cefazolin), and significantly nephrotoxic (gentamicin) And blood urea nitrogen, creatinine, urine β_2-microglobulin, urine retinol binding protein, urine microalbuminuria, urinary IgG, urinary N-acetyl-β-glucosaminidase were measured 1 week after treatment.Results Cefurone (P <0.01 or P <0.05), blood urea nitrogen and creatinine still remained unchanged (P> 0.05), but there was no significant difference between before and after triazine treatment ). When serum creatinine increased mildly in gentamicin group, but the urinary micro-protein increased exponentially. It was indicated that the determination of urinary trace protein could be of clinical significance for the early detection of drug nephrotoxicity.