Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1)cDNA in human genome by Yale University’s Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin wascompletely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the most common cancers.It through includes the cysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs)the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function,simultaneously it also is in the cell division process the chromosome traveler protein(chromosome passenger protein).There are three approaches by which survivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3,caspase-7and caspase-9 in cell receiving apoptotic stimuls;(2)with the Smac/DIABLO function,sends the XIAP activeness to increase,XIAP through directly affects and restrains its function with caspases,achieved restrains function which perishes weakly;(3)through restrains p53 the function to block perishes weakly the process.Survivin expressed specificity and its function multiplicity.Survivin only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues.This kind of expression is been extremely low the cell cycle strict regulation in the G1 time expression,the S time is G1 time 6 times,the G2/M time advances to 40 times,demonstrated its expression has the G2/M time dependence specificity.It has bi-function of inhibiting apoptosis and involving in cell cycle control.Survivin has found in most of tumor cells in recently researches.Survivin expresses generally in all tumor cell line in the American State-run Cancer Research institute anti-tumor medicine screening procedure 60 different tumor cells,in which expresses in the mammary gland cancer cell and the lung cancer cell highly,expresses in the kidney cancer lowly.Survivin except in tumor cell high expression,at breast cancer,tumor in front of and so on endometrium cancer,cervical cancer cancers in the pathological change has the expression.Survivin is over expressed in early malignant,which brokes the balance of proliferation and apoptotic,causes the occurrence of tumor.Obviously,survivin is closely related to the uncontrolled growth carcinogenesis,development and tumorigenesis.Because Survivin in tumor organization’s special expression and perishes weakly in the suppression cell and adjusts in the cell division the vital role,causes it to become one to have the latent application value tumor designated object and the tumor treatment new target spot.The recent research of survivin in the development,treatment and situation of tumor is introduced. Survivin was initially separated in hybridization of Effector Cell Protease Receptor-1 (EPR-1) cDNA in human genome by Yale University’s Ambrosini in 1997, which is member of the inhibitor of apoptosis proteins (IAPS) .Unlike other IAP protein, found during embryonic and fetal development, survivin wascompletely down-regulated and undetectable in normal adult tissues, and became prominently re expressed in all of the most common cancers. It has included the cysteine ​​/ histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats (BIRs) the structure territory directly or intervenes Caspases the function to display display its anti-perishes weakly the function, simultaneously it also is in the cell division process the chromosome traveler protein (chromosome passenger protein). There are three approaches by which survivin inhibits the processing of apoptosis: (1) inhibits processing of down stream effector caspase-3, caspase-7 and caspase-9 in cell receiving apoptotic stimuls; (2) with the S (3) through restrains p53 the function to block perishes weakly the process. survivin expressed specificity and its function multiplicity. Survivin only expresses in tumor tissues and can not be found in normal terminally differentiated tissues. This kind of expression is extremely low the cell cycle strict regulation in the G1 time expression, the S time is G1 time 6 times, the G2 / M time advances to 40 times, said its expression has the G2 / M time dependence specificity. It has bi-function of inhibiting apoptosis and involving in cell cycle control. Survivin has found in most of tumor cells in recent researches. all tumor cell line in the American State-run Cancer Research institute anti-tumor medicine screening procedure 60 different tumor cells, in which expresses in the mammary gland cancer cell and the lung cancer cell highly, expresses in the kidney cancer lowly. Survivin except in tumor cell high expression, at breast cancer, tumor in front of and so on endometrium cancer, cervical cancer cancers in the pathological change has the expression . Survivin is over expressed in early malignant, which brokes the balance of proliferation and apoptotic, causes the occurrence of tumor. Obviously, survivin is closely related to the uncontrolled growth carcinogenesis, development and tumorigenesis. Because Survivin in tumor organization’s special expression and perishes weakly in the suppression cell and adjusts in the cell division the vital role, causes it to become one to have the latent application value tumor designated object and the tumor treatment new target spot. the recent research of survivin in the development, treatment and situation of tumor is introduced.