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目的探讨广东地区瑶族和汉族健康人群谷胱甘肽硫转移酶T1(GSTT1)基因多态性的分布。方法采用双重PCR方法检测226例瑶族和219例汉族人群GSTT1基因型。结果瑶族和汉族人群GSTT1缺失基因型频率分别为47.8%(108/226)及52.1%(114/219),二者之间差异无统计学意义(P>0.05);同民族不同性别之间、不同年龄之间差异亦无统计学意义(P>0.05)。结论广东地区瑶族和汉族人群GSTT1基因多态性分布与中国其他地区汉族人群、韩国人和日本人相似,而与美国黑人和白人显著不同。
Objective To investigate the distribution of glutathione S-transferase T1 (GSTT1) polymorphism in healthy population of Yao and Han in Guangdong. Methods The genotypes of GSTT1 in 226 cases of Han and 219 cases of Han population were detected by double PCR. Results The frequencies of GSTT1 deletion genotypes in Yao and Han were 47.8% (108/226) and 52.1% (114/219), respectively. There was no significant difference between the two genotypes (P> 0.05) There was no significant difference between different ages (P> 0.05). Conclusion The distribution of GSTT1 gene polymorphism in Yao and Han populations in Guangdong is similar to that in other Han Chinese, Koreans and Japanese in China, but significantly different from that of blacks and whites in the United States.