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以２－甲氧基萘为起始原料，经二溴化、脱溴、偶联、缩酮化、重排、水解得ｄｌ－萘普生（１），以２－甲氧基萘计算，总收率为７７％。
Starting from 2-methoxynaphthalene, dibromination, debromination, coupling, ketalization, rearrangement and hydrolysis gave dl-naproxen (1) The total yield is 77%.