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目的与方法用免疫组化SP法观察55例老年膀胱移行细胞癌组织中bc1-2基因产物和突变型P53蛋白表达。bc1-2和P53蛋白表达阳性率分别为41.8％和49.1％,突变型P53与组织学分级、临床分期和转移关系密切（P＜0.05）,bc1-2蛋白表达与肿瘤侵袭性和淋巴结及远处转移有密切的关系（P＜0.05）,但与组织学分级无明显关系（P＞0.05）。结果bc1—2表达与P53在膀胱癌发生中可能起协同作用。结论bc1-2与P53一样可能作为评估肿瘤恶性程度、侵袭性和转移的重要参考指标之一。
Objective To investigate the expression of bc1-2 gene and mutant P53 protein in 55 cases of transitional cell carcinoma of the bladder with immunohistochemical SP method. The positive rates of bc1-2 and P53 protein expression were 41.8% and 49.1% respectively. The expression of bcl-2 protein was significantly correlated with tumor invasion, lymph node and lymph node metastasis (P <0.05) (P <0.05), but not with histological grade (P> 0.05). Results The expression of bcl-2 and P53 may play a synergistic role in the development of bladder cancer. Conclusions bc1-2, like P53, may serve as one of the important reference indexes for assessing the malignancy, invasiveness and metastasis of tumors.