论文部分内容阅读
烧伤、严重创伤、出血性休克、肠梗阻或电离辐射伤等的缺氧和低灌流都造成肠粘膜损伤、增大通透性等肠功能障碍,导致肠细菌移位、局部中性白细胞缺乏、吞噬细胞功能减退等.这都与肠壁氧张力(PO_2)的改变直接相关.近年有人证实用硫酸乙酰肝素(heparan sulfate;danaparoid sodium)可在出血性休克时缓解低灌流对肠粘膜的影响.乙酰肝素从牛肠粘膜备制,对血液流变学特性有作用,其抗血凝的效应仅肝素的1/70.由于乙酰肝素能降低血液粘滞度,从而增进组织氧合,因此在失血等情况应用可保持肠管功能,减少细菌移位等有害影响.有人用D-木糖(D-xylose)的吸收作指标已证明乙酰肝素确有此作用.作者改用带荧光一氧传感装置的张力计放在肠管的浆膜和粘膜上直接测定PO_2,观察研究乙酰肝素作用.
Burn, severe trauma, hemorrhagic shock, intestinal obstruction or ionizing radiation injury such as hypoxia and hypoperfusion caused by intestinal mucosal injury, increased permeability and other intestinal dysfunction, resulting in intestinal bacterial translocation, local neutropenia, Phagocyte dysfunction, etc. This is directly related to the change of intestinal oxygen tension (PO 2) .In recent years, it has been demonstrated that heparan sulfate (heparan sulfate) can alleviate the effect of hypoperfusion on intestinal mucosa during hemorrhagic shock. Preparation of heparan from the bovine intestinal mucosa, the role of the blood rheological properties, the anti-hemostatic effect of only heparin 1/70. Because heparanase can reduce blood viscosity, thereby enhancing tissue oxygenation, so in the blood loss And other applications can maintain bowel function and reduce the harmful effects of bacterial translocation Some people use the absorption of D-xylose (D-xylose) as an indicator has proved that heparan does have this effect.With the use of fluorescence-oxygen sensor device Of tension meter on the serosa and mucosa of the bowel directly measured PO_2 observed heparan role.