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目的研究二精丸多糖对糖尿病大鼠的降血糖作用,并初步探讨其作用机制。方法采用高脂高糖饲料结合小剂量链脲佐菌素(STZ)建立2型糖尿病大鼠模型,并分为模型对照组,二精丸多糖低、中、高剂量组,同时设立正常对照及吡咯列酮组。研究二精丸多糖对糖尿病大鼠的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血清胰岛素(Ins)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标的影响。结果二精丸多糖3个剂量组糖尿病大鼠FBG、HbAlc、TC、TG、LDL降低,Ins、HDL升高,与模型组相比有统计学意义(P<0.05)。结论 二精丸多糖对糖尿病大鼠有降血糖作用,其作用可能与增加Ins水平有关。
Aim To study the hypoglycemic effect of Erzhiwan polysaccharide on diabetic rats and to explore its mechanism. Methods A rat model of type 2 diabetes mellitus was established by using high-fat and high-sugar diet combined with low-dose streptozotocin (STZ). The models were divided into model control group, low-, medium- and high-dose PSPS group, Pyrrolostone group. To investigate the effects of Erjing polysaccharide on fasting blood glucose (FBG), HbA1c, Ins, TC, TG, HDL, Density lipoprotein (LDL) and other indicators. Results The levels of FBG, HbAlc, TC, TG, LDL, Ins and HDL in diabetic rats were significantly decreased compared with those in model group (P <0.05). Conclusion Polysaccharides of sophomores have hypoglycemic effect on diabetic rats, which may be related to the increase of Ins level.