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大白鼠离体输精管试验表明,当浴管中有10~(-8)～3×10~(-7)mol/L的酚妥拉明时,去甲肾上腺素的量-效曲线平行右移,pA_2=6.98。加3×10~(-5)mol/L及10(-4)mol/L的棉酚预先处理后,量-效曲线右移,最大效应压低,pD_2=3.7。将棉酚每日以35mg/kg的剂量分别给予大鼠口服11天及24天。前者的离体输精管,去甲肾上腺素的量-效曲线与对照组接近;后者,曲线的最大效应压低。上述两组大鼠精囊液中游离氨基酸含量与对照组比较均无显著性差异。
Tests of isolated vas deferens in rats showed that when there are 10~(-8)~3*10~(-7)mol/L of phentolamine in the bath tube, the volume-effect curve of norepinephrine is shifted to the right. pA_2=6.98. After addition of 3×10 -5 mol/L and 10(-4) mol/L gossypol, the volume-effect curve shifted to the right, and the maximum effect was reduced, pD_2=3.7. Gossypol was administered orally to rats daily at a dose of 35 mg/kg for 11 days and 24 days. In the former, the volume-effect curve of norepinephrine was similar to that of the control group; in the latter, the maximum effect of the curve was depressed. There was no significant difference in the content of free amino acids in seminal vesicular fluid between the above two groups compared with the control group.