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目的：探讨光量子济疗对临缺血再灌注损伤花生四烯酸代谢的影响及其治疗脑缺血的机制。方法：制作兔脑缺血再灌注模型，分成单纯液体组、光量子液疗组、丹参组、光量子化丹参组和假手术对照组，进行不同的治疗。分别检测各组血与脑组织中血栓素A2（TXA2）和前列环素（PGI2）．计算TXA2/PGI2比值（T/P）。结果：单纯液体组TXA2和PGI2较假手术组不同程度地增高，T／P升高；而光量子液疗组、丹参组和光量子化丹参组PGI2较单纯液体组增高．TXA2和T/P则较单纯液体组降低，以光量子化丹参组对指标的影响最大。结论：脑缺血再灌注损伤出现明显的TXA2－PGI2平衡障碍，丹参和光量子液疗可增加PGI2含量、减少TXA2生成．降低T/P；调节TxA2-PGI2平衡可能是丹参和光量子液疗治疗脑缺血的机制．光量子液疗可协同丹参作用。
OBJECTIVE: To investigate the effect of photochemical therapy on arachidonic acid metabolism during ischemia-reperfusion injury and its mechanism of cerebral ischemia. Methods: Rabbit models of cerebral ischemia-reperfusion were made and divided into simple liquid group, light quantum liquid therapy group, Salvia miltiorrhiza group, light-induced salvia miltiorrhiza group and sham operation control group. Thromboxane A2 (TXA2) and prostacyclin (PGI2) in blood and brain tissue of each group were detected. Calculate TXA2 / PGI2 ratio (T / P). Results: TXA2 and PGI2 in simple liquid group increased to a higher degree and T / P increased than those in sham operation group, while PGI2 in photochemical therapy group, radix salviae miltiorrhizae group and photochemicalized salvia miltiorrhiza group were higher than those in simple liquid group. TXA2 and T / P were lower than the simple liquid group, and the most important was the light quantification Salvia miltiorrhiza group. CONCLUSION: The obvious TXA2-PGI2 imbalance appears in cerebral ischemia-reperfusion injury. Radix Salviae Miltiorrhizae and light quantum liquid therapy can increase PGI2 content and decrease TXA2 production. Reduce T / P; adjust the balance of TxA2-PGI2 may be Salvia and light quantum fluid treatment of cerebral ischemia mechanism. Light quantum liquid synergistic effect of Salvia.