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目的:观察中药消渴健脾胶囊对乌鲁木齐市维吾尔族糖耐量减退(IGT)患者在糖尿病(DM)发病中的作用。方法:以口服75g葡萄糖耐量试验(OGTT)筛查,按ADA诊断标准判定的维吾尔族IGT80例随机分组,进行2年的观察。对照组:按个体情况安排饮食及运动方案,宣传饮食及运动的意义;治疗组:在饮食及运动方案的基础上同时给予消渴健脾胶囊,每日3次,1次4粒。结果:入组时2组基线资料无统计学差异,2年末,对照组空腹血糖(FPG)、OGTT后2小时血糖(2hPC)、空腹甘油三酯(TG)与治疗组比较,差异有显著性;对照组平均每年糖尿病发病率为7.4%,治疗组平均每年糖尿病的发病率为2.9%,比较有显著性差异。结论:研究资料显示,对照组每年糖尿病发病率为7.4%,而加用中药消渴健脾胶囊的治疗组每年糖尿病发病率为2.9%。表明在IGT干预治疗中,中药干预治疗可达到减少糖尿病发生的效果。
OBJECTIVE: To observe the effect of Xiaoke Jianpi capsule on the pathogenesis of diabetes mellitus (DM) in Uygur people with impaired glucose tolerance (IGT) in Urumqi. Methods: Oral 75g glucose tolerance test (OGTT) screening, according to the ADA diagnostic criteria identified 80 cases of Uighur IGT were randomly divided into groups for 2 years of observation. Control group: diet and exercise programs were arranged according to individual conditions to promote the meaning of diet and exercise; treatment group: Xiaoke Jianpi Capsule was given at the same time on the basis of diet and exercise program, 3 times a day, once a day. Results: There was no significant difference in baseline data between the two groups at the time of enrollment. At the end of the two years, there were significant differences in fasting glucose (FPG) between the control group, two hours after the OGTT (2hPC), and fasting triglyceride (TG) compared with the treatment group. The average incidence of diabetes in the control group was 7.4% per year, and the average annual incidence of diabetes in the treatment group was 2.9%. There was a significant difference. Conclusion: The study data showed that the incidence of diabetes in the control group was 7.4% per year, while the incidence of diabetes per year in the treatment group supplemented with Xiaoke Jianpi capsules was 2.9%. It shows that in the treatment of IGT intervention, Chinese medicine intervention treatment can reduce the incidence of diabetes.