论文部分内容阅读
[目的]探讨子宫内膜癌(endometrial carcinoma,EC)临床病理因素和生物学因素如骨桥蛋白(OPN)、尿激酶型纤溶酶原激活物(uPA)对EC手术预后的影响并筛选出最显著影响因素。[方法]选取171例经病理检查确诊为EC的患者,采用Kaplan-Meier法和Log-rank检验来评价各因素与EC患者生存时间的关系,并用Cox风险模型进行多因素分析。[结果]单因素分析显示手术—病理分期、肌层浸润深度、淋巴结转移、OPN阳性表达及uPA阳性表达5个因素与预后相关(P<0.05),年龄、组织学分化、组织学类型与预后不相关(P>0.05)。Cox多因素分析显示:手术—病理分期、肌层浸润深度、OPN阳性表达、uPA阳性表达是影响预后的独立因素。[结论]手术—病理分期晚、肌层浸润深、OPN表达阳性、uPA表达阳性的EC患者预后差,OPN和uPA有望成为反映EC生物学特性及评价EC预后的重要分子标记。
[Objective] To investigate the clinical and pathological factors of endometrial carcinoma (EC) and biological factors such as osteopontin (OPN) and urokinase-type plasminogen activator (uPA) on the prognosis of EC and screened out The most significant factor. [Methods] A total of 171 patients diagnosed as EC by pathology were selected. Kaplan-Meier method and Log-rank test were used to evaluate the relationship between each factor and the survival time of EC patients. Cox risk model was used for multivariate analysis. [Results] Univariate analysis showed that there were 5 factors related to prognosis (P <0.05), such as age, histological differentiation, histological type and prognosis Not related (P> 0.05). Cox multivariate analysis showed that the surgical-pathological stage, the depth of myometrial invasion, the positive expression of OPN and the positive expression of uPA were independent prognostic factors. [Conclusion] The prognosis of EC patients with late stage of operation-pathology, deep myometrial invasion, positive expression of OPN and uPA expression is poor. OPN and uPA are expected to become important molecular markers to reflect the biological characteristics of EC and evaluate the prognosis of EC.