白血病抑制因子 (LIF)是一种能在多种细胞中发挥多种生物学效应的多功能细胞因子。在子宫内膜 ,LIF的表达水平呈月经周期依赖性 ,其峰值与植入期一致 ,是着床的关键因子。排卵前后卵泡液中LIF显著增高 ,提示LIF与排卵 ,早期胚胎发育 ,植入密切相关。LIF可促进体外培养胚胎的胚泡形成和孵化 ,提高胚胎质量和着床率。LIF的表达受母体激素和细胞因子的调控。 Leukemia Inhibitory Factor (LIF) is a multifunctional cytokine that exerts multiple biological effects in a variety of cells. In the endometrium, the expression level of LIF is dependent on the menstrual cycle and its peak coincides with the implantation period, which is the key factor for implantation. Before and after ovulation follicular fluid LIF was significantly higher, suggesting that LIF and ovulation, early embryo development, implantation is closely related. LIF can promote embryo blastocyst formation and hatching in vitro and improve embryo quality and implantation rate. The expression of LIF is regulated by maternal hormones and cytokines.