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目的观察丙硫氧嘧啶联合左甲状腺素治疗Grave’s病的效果。方法该院收治的Grave’s病患者98例,按随机数字表法分为观察组与对照组各49例。两组均常规对症支持治疗及丙硫氧嘧啶片口服,观察组联合左甲状腺素钠片口服。治疗3个月后观察甲状腺功能指标,包括血清游离三碘甲状腺原氨酸(FT3)、总三碘甲状腺原氮酸(TT3)、游离甲状腺素(FT4)、总甲状腺激素(TT4)、血清甲状腺球蛋白抗体(TGAb)和抗甲状腺过氧化物酶抗体(TPOAb)水平变化等。结果观察组总有效率91.8%高于对照组的75.5%,FT3、TT3、FT4、TT4、TGAb、TPOAb水平和复发率低于对照组,组间差异均有统计学意义。结论丙硫氧嘧啶联合左甲状腺素钠治疗Grave’s病,效果优于单用丙硫氧嘧啶治疗。
Objective To observe the effect of propylthiouracil and levothyroxine in the treatment of Grave’s disease. Methods A total of 98 patients with Grave’s disease admitted to our hospital were divided into observation group and control group according to random number table. Both groups were routine symptomatic and supportive treatment with propylthiouracil tablets orally, the observation group combined with levothyroxine sodium tablets orally. Thyroid function indexes were observed after 3 months of treatment, including serum free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroid hormone (TT4), serum thyroid Globulin antibody (TGAb) and anti-thyroid peroxidase antibody (TPOAb) levels change. Results The total effective rate in the observation group was 91.8% higher than that in the control group (75.5%). The levels of FT3, TT3, FT4, TT4, TGAb, TPOAb and recurrence were lower than those in the control group. Conclusions Propylthiouracil and levothyroxine are superior to propylthiouracil in the treatment of Grave’s disease.