目的探讨内镜辅助下经眶上锁孔入路切除大型垂体腺瘤的应用价值。方法选择30例大型垂体腺瘤患者,采用内镜辅助下经眶上锁孔入路行手术切除肿瘤。结果垂体腺瘤手术中经眶上锁孔入路可获得与传统开颅手术相当的显微镜下暴露,垂体瘤切除满意,术后随访6个月～2年,均未见肿瘤复发,术后住院较常规开颅平均缩短约3～4d。结论在内镜辅助下经眶上锁孔入路切除大型垂体腺瘤是一个理想的手术方式。 Objective To investigate the application value of endoscopic supraorbital keyhole approach in the removal of large pituitary adenomas. Methods Thirty patients with large pituitary adenomas were selected. The tumors were surgically resected through the supraorbital keyhole approach using endoscope assisted approach. RESULTS Pituitary adenoma underwent supraorbital keyhole approach with comparable exposure to conventional craniotomy under microscopy. The pituitary tumor was resected satisfactorily. No tumor recurrence was observed after follow-up for 6 months to 2 years. Compared with conventional craniotomy, the average shortening is about 3 to 4 days. Conclusion Endoscopic supraorbital approach to resection of large pituitary adenomas is an ideal surgical approach.