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雷公藤在风湿免疫性疾病与肾脏疾病的临床疗效显著,但其毒副作用限制了其在许多领域的应用。其毒副作用主要表现在消化、生殖、血液、免疫等系统。因此,雷公藤制剂的减毒持效研究成为近年的焦点。作者对1999～2011年雷公藤减毒研究的相关文献48篇进行了检索分析。由文献可知传统上的雷公藤减毒方法包括剂型改革、炮制及中药配伍等。近年来出现的双向固体发酵技术可获取雷公藤新药材,为雷公藤减毒持效研究拓宽了思路,值得进一步推广应用。今后需将传统中医理论与现代药理药效机制结合,借助于现代检测方法,揭示其减毒持效的机制,为雷公藤制剂的新药研发提供依据。
Tripterygium has a significant clinical effect on rheumatic immunity and kidney disease, but its toxicity has limited its application in many fields. Its toxic side effects mainly in the digestive, reproductive, blood, immune and other systems. Therefore, triptolide attenuated drug efficacy research has become the focus of recent years. The author of the literature from 1999 to 2011 triptolide attenuated 48 articles were searched and analyzed. From the literature we can see that the traditional method of triptolide attenuated, including formulation reform, processing and compatibility of traditional Chinese medicine. In recent years, two-way solid fermentation technology can be obtained new Tripterygium medicinal herbs for the study of triptolide attenuated to broaden the train of thought, it is worth further promotion and application. In the future, it is necessary to combine the traditional Chinese medicine theory with modern pharmacological and pharmacodynamic mechanisms, and to reveal the mechanism of its attenuation and persistence by means of modern detection methods to provide the basis for the research and development of new drugs of Tripterygium preparations.