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莫达非尼(modafin il)于1994年首次在法国上市,商品名Mod iodal,用于治疗发作性睡眠症和嗜睡性多眠症,其化学结构见图1。莫达非尼的药理特征不同于拟交感神经药物,而与脑中抑制性神经递质γ-氨基丁酸(GABA)的减少有关,并对5-羟色胺(5-HT)和去甲肾上腺素有调控作用[1]。1998年莫
Modafinil was first marketed in France in 1994 under the trade name Mod iodin for the treatment of narcolepsy and lethargy and hypnotism, and its chemical structure is shown in Figure 1. The pharmacological properties of modafinil are different from those of sympathomimetic drugs and are related to the reduction of GABA, an inhibitory neurotransmitter in the brain. The effects of 5-hydroxytryptamine (5-HT) and norepinephrine A regulatory role [1]. 1998 Mo