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目的:探讨脂肪肝患者载脂蛋白B、CⅢ、E基因多态性与血脂的关系。方法:采用基因芯片技术对118例脂肪肝患者进行了载脂蛋白B、CⅢ、E的基因多态性位点分析.并测定其血脂等血生化指标。结果:载脂蛋白B、CⅢ、E3种基因各多态性位点与所选择血生化指标变化无明显关联(P>0.05)。结论:可能载脂蛋白B、CⅢ、E基因多态性并不影响脂肪肝患者的血脂水平。
Objective: To investigate the relationship between the polymorphisms of apolipoprotein B, C Ⅲ, E and blood lipids in patients with fatty liver. Methods: The gene polymorphisms of apolipoprotein B, C Ⅲ and E in 118 patients with fatty liver were analyzed by gene chip technique, and the blood biochemical parameters such as serum lipids were determined. Results: The polymorphisms of apolipoprotein B, CⅢ and E3 genes had no significant correlation with the changes of blood biochemical parameters (P> 0.05). Conclusion: It is probable that apolipoprotein B, C Ⅲ, E polymorphisms do not affect the level of blood lipids in patients with fatty liver.