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目的探讨甲状腺乳头状癌组织中S-100阳性树突状细胞及淋巴细胞浸润与颈部淋巴结转移的关系。方法 50例甲状腺乳头状癌行颈部淋巴结清扫术患者,采用免疫组织化学方法检测甲状腺癌组织中S-100阳性树突状细胞及淋巴细胞浸润情况,分为S-100阳性树突状细胞及淋巴细胞阳性浸润者(A组)与单独S-100阳性树突状细胞或淋巴细胞浸润者(B组),均行术后颈部淋巴结组织病理检查,比较2组颈部淋巴结转移率。结果 A组颈部淋巴结转移率(27.78%)低于B组(78.12%),2组比较差异有统计学意义(P<0.05)。结论甲状腺乳头癌组织中S-100阳性树突状细胞及淋巴细胞浸润情况与颈部淋巴结转移密切相关。
Objective To investigate the relationship between S-100-positive dendritic cells and lymphocyte infiltration and cervical lymph node metastasis in papillary thyroid carcinoma. Methods Fifty patients with papillary thyroid carcinoma underwent neck lymph node dissection. The infiltration of S-100 positive dendritic cells and lymphocytes in thyroid carcinoma tissues was detected by immunohistochemistry. The cells were divided into S-100 positive dendritic cells Lymphatic positive infiltrating (group A) and S-100 positive dendritic cells alone or lymphocyte infiltrating (group B) were performed postoperative neck lymph node histopathological examination, the cervical lymph node metastasis rate was compared between the two groups. Results The rate of cervical lymph node metastasis in group A was lower than that in group B (27.78%) (78.12%). The difference between the two groups was statistically significant (P <0.05). Conclusion S-100 positive dendritic cells and lymphocyte infiltration in papillary thyroid carcinoma are closely related to cervical lymph node metastasis.