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传统医学发现和认识疾病,是从病人的症状、体征和检验的异常指标出现开始的。以脱氧核糖核酸(DNA)双螺旋结构的发现为转折,20世纪后半叶进入了分子生物学时代,人们对生命和疾病现象的认识逐渐深入到分子水平。随着蛋白质一级结构(氨基酸顺序)和高级结构研究技术的突破,在病人体内形态异常的红血球中,发现了结构和功能异常的血红蛋白分子(Hbs)并命名了第一个“分子病”即镰刀状贫血病。分子病的发现标志着正常和
Traditional medicine to find and recognize the disease, from the patient’s symptoms, signs and abnormal indicators of the test began. With the discovery of double helix structure of DNA as a turning point, the second half of the 20th century entered the era of molecular biology, and people’s understanding of the phenomenon of life and disease gradually went to the molecular level. With the breakthrough of protein primary structure (amino acid sequence) and advanced structural research techniques, structural and dysfunctional hemoglobin molecules (Hbs) were found in morphologically abnormal erythrocytes and named the first “molecular disease” Sickle-shaped anemia. The discovery of molecular disease marks normal and