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青霉烷酸S-亚砜(1)和6α-溴(氯)代青霉烷酸S-亚砜(2)是合成某些β-内酰胺酶抑制剂,例如BL-P 2013(3)、YTR-830(4)的重要中间体。本文介绍不采用任何溶剂或酸,用30%的过氧化氢氧化对应的酸制备青霉烷酸和6α-溴(氯)代青霉烷酸(S)-亚砜的简便方法。方法是在搅拌和冷却下,向油状青霉烷酸或6α-溴(氯)代青霉烷酸加入30%的过
Penicillic acid S-sulfoxide (1) and 6α-bromo penicillanic acid S-sulfoxide (2) are compounds that synthesize certain β-lactamase inhibitors such as BL-P 2013 (3) , YTR-830 (4) of the important intermediates. This article presents a simple and convenient method for the preparation of penicillanic acid and 6α-bromo-chloro penicillanic acid (S) -sulfoxide without oxidizing or oxidizing the corresponding acid with 30% hydrogen peroxide using any solvent or acid. The method comprises adding 30% oily penicillanic acid or 6α-bromo (chloro) penicillanic acid to oily penicillanic acid under stirring and cooling