论文部分内容阅读
目的分析脊索样脑膜瘤的临床病理特征。方法观察6例脊索样脑膜瘤患者肿瘤组织HE染色病理表现及肿瘤组织免疫组化标记物的表达,并结合文献分析临床病理特征。结果HE染色镜下见黏液样嗜碱性基质中分布小梁状或条索状排列的肿瘤细胞,细胞质淡染或嗜酸,部分细胞呈液滴状类似脊索瘤样细胞,可见典型脑膜瘤结构。免疫组化结果示,上皮膜抗原和波形蛋白均阳性表达,而广谱细胞角蛋白和胶质纤维酸性蛋白阴性表达。结论结合临床组织病理学和免疫组化检测有助于诊断脊索样脑膜瘤。
Objective To analyze the clinicopathological features of chorda-like meningiomas. Methods The pathological findings of tumor tissue and the expression of immunohistochemical markers of tumor in 6 cases of spinal meningioma were observed. The clinical and pathological features were analyzed in combination with the literature. Results Hematoxylin-eosin staining found in mucin-like basophilic trabecular or stromal arrangement of tumor cells, light cytoplasm or eosinophilic, some cells were similar droplet like chordoma-like cells, showing typical meningioma structure . Immunohistochemical results showed that the epithelial membrane antigen and vimentin were positive expression, while the broad-spectrum cytokeratin and glial fibrillary acidic protein negative expression. Conclusion Combined with clinical histopathology and immunohistochemical detection is helpful to diagnose chorda-like meningioma.