六、消炎痛与速尿、安体舒通众所周知消炎痛在人和实验动物中都是速尿的拮抗剂,并具有钠水潴留作用而加重心衰。曾有一例报告患有严重心衰的病人应用消炎痛与利尿剂疗法而产生相互作用。该病人男性63岁,患严重心衰伴有肺水肿和腿部水肿。接受地高辛、速尿、安体舒通、二硝酸异山梨醇酯和别嘌呤醇治疗,病人又发生急性痛风,加用消炎痛(200mg/日),心衰的临床体症加重。然后用氟联苯丙酸(150mg/日)代替消炎痛。第二天 Sixth, indomethacin and furosemide, spironolactone indomethacin is well known in humans and laboratory animals are furosemide antagonist, and with sodium and water retention and increase heart failure. In a previous report, patients with severe heart failure developed an interaction with indomethacin and diuretic therapy. The patient, a 63-year-old man with severe heart failure, had pulmonary edema and leg edema. Receiving digoxin, furosemide, spironolactone, isosorbide dinitrate and allopurinol treatment, the patient developed acute gout, plus indomethacin (200mg / day), clinical manifestations of heart failure worsened. Indomethacin was then replaced with flurbiprofen (150 mg / day). the next day