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近年来 ,糖尿病的发病率逐渐增高。研究证实肾素 -血管紧张素 -醛固酮系统 (RAAS)在糖尿病肾病 (DN )的发生、发展中起重要作用 ,肾内血流动力学改变直接参与 DN的发生 ,而肾小球高滤过则在其中起关键作用。糖尿病早期就可以出现肾小球高滤过 ,血管紧张素转换酶抑制剂 (ACE- I)
In recent years, the incidence of diabetes gradually increased. Studies have shown that renin-angiotensin-aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy (DN). Renal hemodynamic changes are directly involved in the development of DN, while hyperfiltration of glomeruli In which play a key role. Glomerular hyperfiltration can occur early in diabetes, angiotensin converting enzyme inhibitors (ACE-I)