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目的:分析拉莫三嗪(LTG)治疗儿童癫痫的疗效及影响疗效的因素。方法:选取2012年5月至2014年11月于北京大学第一医院小儿神经科门诊就诊及病房住院的癫痫患儿为研究对象,回顾性分析应用拉莫三嗪治疗的临床资料,进行疗效评价;分析性别、起病年龄、起病前发育情况、发作类型、加用拉莫三嗪时的病程、单药/添加治疗、血药浓度等对拉莫三嗪疗效的影响。结果:185例患儿纳入研究,无发作率16.2%,有效率38.9%,无效率44.9%,总有效率55.1%;单因素分析显示,起病前发育情况(P=0.002)及发作形式(P=0.072)与拉莫三嗪疗效相关;经多因素分析,仅起病前发育情况与疗效相关[OR=2.67,95%CI(1.39,5.10),P=0.003]。结论:拉莫三嗪治疗儿童癫痫有一定的疗效,患儿起病前发育情况与拉莫三嗪疗效相关。
Objective: To analyze the efficacy of lamotrigine (LTG) in the treatment of children with epilepsy and the factors influencing the curative effect. Methods: From May 2012 to November 2014 in Peking University First Hospital Pediatric Neurology outpatient visits and ward hospitalized epilepsy children as the research object, retrospective analysis of clinical data using lamotrigine treatment, the efficacy evaluation The effect of lamotrigine on the sex, onset age, pre-onset development, seizure type, course of treatment with lamotrigine, monotherapy / addition therapy and plasma concentration were analyzed. Results: One hundred and eighty-five children were enrolled in the study, with no seizure rate of 16.2%, effective rate of 38.9%, inefficiency rate of 44.9%, and total effective rate of 55.1%. Univariate analysis showed that pre-onset development (P = 0.002) P = 0.072) was associated with the efficacy of lamotrigine; by multivariate analysis, pre-onset development was associated with efficacy only (OR = 2.67, 95% CI 1.39, 5.10, P = 0.003). Conclusions: Lamotrigine has a certain effect in the treatment of childhood epilepsy. The development of the patient before onset is related to the efficacy of lamotrigine.