论文部分内容阅读
目的了解四川省2005-2008年健康人群脑膜炎奈瑟菌(Nm)带菌状况、抗体水平及其动态变化趋势,为制定流脑防控对策提供依据。方法采集健康人群咽拭子并进行脑膜炎奈瑟菌分离培养,采集健康人群血清进行抗体水平检测,计算健康人群流脑带菌率、血清保护性抗体阳性率。结果健康人群Nm带菌率为1.40%,B群所占比例为91.80%,健康人群A群流脑的血清保护性抗体阳性率为70.73%,C群为31.39%,3岁以下幼儿A群和C群流脑血清保护性抗体阳性率分别为47.10%和21.24%,均低于3～14岁儿童(71.55%和31.84%),差异有统计学意义(χ2值分别为106.69和21.69,P<0.01)。结论四川省Nm带菌以B群带菌为主,3岁以下儿童流脑血清保护性抗体阳性率较低。
Objective To understand the status of bacteria-borne infection, antibody levels and trends of Neisseria meningitides (Nm) in healthy population from 2005 to 2008 in Sichuan Province, and to provide evidence for the prevention and control of meningococcal disease. Methods Throat swabs of healthy people were collected and Neisseria meningitidis was isolated and cultured. The serum of healthy people was collected to detect the antibody levels, and the prevalence of meningococcal meningitis and serum protective antibodies were calculated. Results The prevalence of Nm was 1.40% in healthy population and 91.80% in B group. The positive rate of serum protective antibodies in group A was 70.73%, in group C was 31.39%, in group A and C The positive rates of serum protective antibodies in group M were 47.10% and 21.24%, respectively, which were lower than those in children aged 3-14 years (71.55% and 31.84% respectively) (χ2 = 106.69 and 21.69, P <0.01 ). Conclusion The population of Nm-carrying bacteria in Sichuan Province is mainly B-banding, and the positive rate of serum protective antibodies in children under 3 years old is lower.