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采用介质研磨法制备尼莫地平纳米混悬剂以提高药物溶解度。以粒径、多分散系数(PDI)、ζ电位为指标,采用单因素法优化其处方和工艺。优化后制品的粒径为(261.2±5.7)nm、PDI为0.160±0.022、ζ电位为-32 mV。X射线粉末衍射和差示扫描量热分析结果表明纳米冻干粉中药物仍以晶型状态存在。与原药相比,纳米冻干粉的饱和溶解度提高了近60倍。
Preparation of nimodipine nanosuspension by media milling method to improve drug solubility. The particle size, polydispersity (PDI) and zeta potential were used as indexes to optimize the formulation and technology by single factor method. The particle size of the optimized product was (261.2 ± 5.7) nm, the PDI was 0.160 ± 0.022, and the zeta potential was -32 mV. X-ray powder diffraction and differential scanning calorimetry analysis showed that the drugs in the nano lyophilized powder still exist in the crystalline state. Compared with the original drug, the saturated solubility of nano freeze-dried powder increased by nearly 60 times.