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目的:探讨研究步长稳心颗粒联合胺碘酮治疗急性心肌梗死伴心房颤动的临床疗效。方法:将40例高龄老人急性心肌梗死伴心房颤动患者随机分为观察组和对照组,观察组给予步长稳心颗粒联合胺碘酮治疗,对照组给予胺碘酮治疗,治疗结束后,观察两组临床治疗效果、心电图变化、转复时间及不良反应情况。结果:治疗后观察组总有效率为95.0%,对照组总有效率为75.0%;两组患者治疗前后收缩压、舒张压、P-R间期、QTc等无显著变化(P>0.05),心率和QT-间期有显著性差异(P<0.05);观察组患者住院时间、转复时间和院内病死率低于对照组,窦性心律维持率和心房颤动发作控制率高于对照组;观察组不良反应例数低于对照组,两组治疗效果比较具有显著性差异,观察组疗效优于对照组。结论:步长稳心颗粒联合胺碘酮治疗高龄老人急性心肌梗死伴心房颤动临床效果显著,安全快速,用药后不良反应发生率低,值得临床推广应用。
Objective: To investigate the clinical efficacy of Wenxin Granule combined with amiodarone in the treatment of acute myocardial infarction with atrial fibrillation. Methods: Forty elderly patients with acute myocardial infarction and atrial fibrillation were randomly divided into observation group and control group. The observation group was given Buchang Wenxin Granule combined with amiodarone, while the control group was treated with amiodarone. After treatment, the observation was made Two groups of clinical treatment, ECG changes, recovery time and adverse reactions. Results: After treatment, the total effective rate was 95.0% in the observation group and 75.0% in the control group. There was no significant change in systolic blood pressure, diastolic blood pressure, PR interval and QTc before and after treatment in both groups (P> 0.05) QT-interval had significant difference (P <0.05); the observation group patients in hospital time, recovery time and hospital mortality was lower than the control group, sinus rhythm maintenance rate and atrial fibrillation control rate was higher than the control group; observation group The number of adverse reactions was lower than that of the control group, the treatment effect was significantly different between the two groups, and the observation group was superior to the control group. Conclusion: The step-stabilizing granule combined with amiodarone is effective in treating elderly patients with acute myocardial infarction and atrial fibrillation. The clinical effect is rapid and safe. The incidence of adverse reactions is low, which is worthy of clinical application.