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目的探讨早期糖尿病肾病患者血清中同型半胱氨酸(Hcy)和胱抑素C(CysC)水平的变化及其意义。方法分别应用酶法和免疫比浊法检测100例早期糖尿病肾病患者和100例健康对照者血清中Hcy和CysC水平的变化。结果早期糖尿病肾病组血清中同型半胱氨酸和胱抑素C水平显著高于对照组,差异有统计学意义(P<0.05)。结论血清中Hcy和Cys-C水平变化可作为早期糖尿病肾病患者早期肾损伤一个理想的指标,两者联合检测对早期糖尿病肾病诊断具有重要意义。
Objective To investigate the changes of serum homocysteine (Hcy) and cystatin C (CysC) in patients with early diabetic nephropathy and its significance. Methods Serum levels of Hcy and CysC in 100 patients with early diabetic nephropathy and 100 healthy controls were detected by enzymatic and immunoturbidimetric methods respectively. Results Serum levels of homocysteine and cystatin C in early diabetic nephropathy group were significantly higher than those in control group (P <0.05). Conclusion The changes of serum Hcy and Cys-C levels may be an ideal indicator of early renal injury in patients with early diabetic nephropathy. The combined detection of these two levels is of great significance in the diagnosis of early diabetic nephropathy.