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目的检测糖尿病大鼠胃肌间丛神经元尼氏体的变化。方法应用链脲佐菌素建立SD大鼠糖尿病模型,成模30周后,采用甲苯胺蓝染色法检测糖尿病30周大鼠、中药治疗组及正常对照组的胃肌间丛神经元尼氏体。结果糖尿病30周大鼠胃肌间丛神经元尼氏体数量少于正常对照组(P<0.01);而中药治疗组数量较多,与正常对照组无统计学差异。结论糖尿病30周大鼠胃肌间丛神经元尼氏体数量减少,显示神经损害;中药治疗组尼氏体数量较多,显示中药的保护作用。
Objective To detect the changes of Nissl body in gastric myenteric plexus neurons in diabetic rats. Methods Streptozotocin (STZ) was used to establish a diabetic rat model of SD. After 30 weeks of modeling, toluidine blue staining was used to detect Nissl body of gastric myenteric plexus neurons in 30-week diabetic rats, TCM-treated group and normal control group . Results The number of Nissl bodies in gastric myenteric plexus neurons in diabetic rats at 30 weeks was less than that in normal controls (P <0.01). However, the number of TCM treated groups was significantly higher than that of normal controls. Conclusions The number of Nissl body in gastric myenteric plexus decreases after 30-day diabetes mellitus, which shows nerve damage. The number of Nissl body in traditional Chinese medicine treatment group is large, which shows the protective effect of traditional Chinese medicine.