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溶栓疗法治疗急性心肌梗塞(AMI)系施行越早则疗效越好。很多医院仅对发病6小时以内的患者施行溶栓疗法。尤素福等报告.超过6小时以上的晚期溶栓疗法仍可使AMI患者死亡率降低28%。从而提示晚期溶栓疗法仍可能是有益的。 晚期溶栓疗法疗效的机理 准确确定急性冠状动脉闭塞的发生时间常常是很困难的.对于胸痛性质不恒定者则更难。通常把胸痛开始或开始加重时作为冠状动脉闭塞发生的时间.对于在晚期溶栓疗法的研究中的某些病例,也可能在其冠状动脉闭塞前的时间系心绞痛发作,而被误作为
Thrombolytic therapy for acute myocardial infarction (AMI) Department of the implementation of the earlier the better. Many hospitals administer thrombolytic therapy only to patients within 6 hours of onset. Yusuf et al reported that advanced thrombolytic therapy lasting more than 6 hours could still reduce the mortality rate of AMI patients by 28%. Suggesting that advanced thrombolytic therapy may still be beneficial. Therapeutic Mechanisms of Advanced Thrombolytic Therapy It is often difficult to accurately determine the timing of acute coronary occlusion and more difficult for patients with unstable chest pain. The onset of coronary occlusion is usually defined as the onset of chest pain or when it begins to aggravate It is also possible that in some cases in the study of advanced thrombolytic therapy angina pectoris occurred at times before its occlusion and mistakenly