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目的:文章以古籍文献中射干用堇竹叶炮制为切入点,从组分变化角度对射干减毒增效作用进行研究。方法:按古籍中的方法用堇竹叶制射干,煎煮时间从午时至亥时;采用高效液相色谱法,测定射干与堇竹叶共煎前后,射干药材中异黄酮苷类成分射干苷、野鸢尾苷及苷元成分鸢尾黄素的含量。结果:与堇竹叶煎煮后,射干苷和野鸢尾苷分别减少了44.88%和65.25%、鸢尾黄素含量基本不变。结论:堇竹叶制射干后,药材中各异黄酮成分含量变化差别较大,黄酮苷类成分被去除较多,故推测射干减毒增效作用机制之一,可能与炮制后射干中异黄酮成分变化有关。
OBJECTIVE: In this paper, the stem-core shoots of Cordyceps mongolicum were treated as the breakthrough points in the ancient literature, and the attenuation and synergism of the stems and shoots were studied from the perspective of composition change. Methods: According to the ancient method, the leaves of Pansy bamboo shoots were radiated and the decocting time was from noon to the sea hours. The contents of isoflavone glycosides in Shegan herbs were determined by high performance liquid chromatography (HPLC) Wild tectori glycosides and aglycone content of tectorigenin content. Results: After decocting the leaves of cordy-brown bamboo leaves, the content of eradication glycosides and iris glycosides decreased by 44.88% and 65.25%, respectively, and the content of tectorihin remained unchanged. CONCLUSION: After the leaves are dried, the contents of isoflavones in medicinal materials vary greatly, and flavonoid glycosides are more removed. Therefore, it is estimated that one of the mechanisms of synergistic effects of synergistic effects of synergistic effects may be related to isoflavones Changes in composition.