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AmAn治疗梅尼埃病可通过全身(肌注、皮下注射)、鼓室及迷路开窗等方法给药。为了比较不同给药途径的影响,作者选择皮下注射和外半规管开窗两种方法,观察了链霉素(SM)对于正常豚鼠及迷路积水模型内耳组织的作用。迷路积水组(n=12)阻断内淋巴管,34～81天后每日皮下注射SM250mg/kg,共10天,30天后处死。正常组(n=16)行外半规管开窗(0.14mm~2)。1克SM溶于3.5ml蒸馏水,用一块浸有SM液的明胶海绵覆盖骨窗。
AmAn treatment Meniere’s disease can be administered by systemic (intramuscular, subcutaneous injection), tympanic and labyrinthine and other methods. In order to compare the effects of different routes of administration, the authors selected two methods, subcutaneous injection and external semicircular canal windowing, to observe the effect of streptomycin (SM) on the inner ear tissue of normal guinea pigs and labyrinthine hydronephrosis models. Lost hydronephrosis group (n = 12) blocked the lymphatic vessels, 34 to 81 days after the daily subcutaneous injection of SM250mg / kg, a total of 10 days, 30 days after sacrifice. Normal group (n = 16) outside the semicircular canal fenestration (0.14mm ~ 2). 1g SM dissolved in 3.5ml distilled water, covered with a gelatin sponge soaked in SM liquid bone window.