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紫杉醇是目前应用最为广泛的抗肿瘤药物之一,主要通过稳定微管和抑制微管解聚而阻滞细胞周期、诱导细胞凋亡等机制杀灭癌细胞,临床主要用于卵巢癌、乳腺癌、非小细胞肺癌、卡波式肉瘤等多种肿瘤性疾病的治疗。随着研究的深入,发现紫杉醇对于诸如血管性疾病、肺动脉高压、纤维增生性疾病、炎症性疾病和神经损伤性疾病等非肿瘤性疾病的治疗具有一定的应用前景。主要对紫杉醇在非肿瘤性疾病中的研究进展进行综述,为开拓紫杉醇的临床应用提供参考。
Paclitaxel is currently one of the most widely used anti-tumor drugs, mainly through the stabilization of microtubules and depolymerization microtubules block cell cycle, induce apoptosis and other mechanisms to kill cancer cells, clinically used in ovarian cancer, breast cancer , Non-small cell lung cancer, Kaposi sarcoma and other tumor diseases. With the deepening of the research, paclitaxel has been found to have certain application prospects in the treatment of non-neoplastic diseases such as vascular diseases, pulmonary hypertension, fibrotic diseases, inflammatory diseases and nerve injury diseases. This review summarizes the research progress of paclitaxel in non-neoplastic diseases and provides a reference for developing the clinical application of paclitaxel.