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目的定量检测抗环瓜氨酸肽抗体(anti-CCP)水平,并探讨其在类风湿性关节炎中的诊断价值。方法分别用ELISA法、免疫散射比浊法检测RA患者和非RA自身免疫性疾病患者血清中的抗CCP抗体和RF水平,并进行评价分析。结果抗CCP抗体对RA诊断的敏感性为82.97%,特异性为94.59%,阳性预测值和阴性预测值分别为95.12%和81.39%,联合RF检测对RA诊断的特异度和阳性预测值可分别提高到97.29%和96.61%。RA组中病程1年以上抗CCP抗体水平(403.90±237.52)RU/ml显著高于病程1年以下患者的抗体水平(288.28±105.35)RU/ml。结论抗CCP抗体对RA的诊断价值优于RF,其抗体水平与病程有关。与RF联合检测可进一步提高RA的诊断特异性。
Objective To quantitatively detect the level of anti-cyclic citrullinated peptide antibody (anti-CCP) and to explore its diagnostic value in rheumatoid arthritis. Methods Anti-CCP antibody and RF level in serum of patients with RA and non-RA autoimmune diseases were detected by ELISA and immune nephelometry, respectively, and evaluated. Results The sensitivity and specificity of anti-CCP antibody for diagnosis of RA were 82.97% and 94.59%, respectively. The positive predictive value and negative predictive value were 95.12% and 81.39% respectively. The specificity and positive predictive value of combined detection of RF to RA were Increased to 97.29% and 96.61%. The anti-CCP antibody level (403.90 ± 237.52) RU / ml over 1 year in RA group was significantly higher than that of patients under 1 year (288.28 ± 105.35) RU / ml. Conclusion The anti-CCP antibody is superior to RF in the diagnosis of RA. The antibody level is related to the course of the disease. Combined with RF can further improve the diagnostic specificity of RA.