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目的探讨卡波西肉瘤组织中基质交感分子1(STIM1)蛋白的表达及临床意义。方法用免疫组织化学方法检测34例卡波西肉瘤、22例血管瘤、15例正常皮肤组织石蜡标本中STIM1蛋白的表达水平,并与卡波西肉瘤的临床病理特征进行统计学分析。结果 STIM1蛋白在3种组织均有不同程度的表达,其中卡波西肉瘤中表达阳性率为79.41%,血管瘤中为81.81%,正常皮肤组织中为13.33%。STIM1在卡波西肉瘤组织和血管瘤组织中的表达水平差异无统计学意义(P>0.05),但两者与正常皮肤组织相比差异均有统计学意义(P<0.05)。STIM1蛋白的表达水平与卡波西肉瘤病理分期呈正相关(rs=0.611,P<0.05),结节期高于斑片期和斑块期(P<0.05)。STIM1的表达水平与民族、性别、年龄、人疱疹病毒8型(HHV-8)感染、人类免疫缺陷病毒(HIV)感染、皮损面积等无明显相关性(P>0.05)。HIV合并HHV-8双阳性和HIV合并HHV-8双阴性的患者中STIM1蛋白的表达水平差异无统计学意义(P>0.05)。结论 STIM1在卡波西肉瘤组织结节期的表达高于斑片期和斑块期,可能对卡波西肉瘤的病程进展起重要作用。
Objective To investigate the expression of STIM1 in Kaposi’s sarcoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of STIM1 protein in 34 cases of Kaposi’s sarcoma, 22 cases of hemangiomas and 15 cases of normal skin tissues. The pathological features of Kaposi’s sarcoma were analyzed statistically. Results The STIM1 protein was expressed in 3 different tissues. The positive rate of STIM1 protein was 79.41% in Kaposi’s sarcoma, 81.81% in hemangiomas and 13.33% in normal skin tissues. There was no significant difference in the expression of STIM1 in Kaposi’s sarcoma and hemangioma (P> 0.05), but the difference between them was statistically significant (P <0.05). The expression of STIM1 protein was positively correlated with the pathological stage of Kaposi’s sarcoma (rs = 0.611, P <0.05), and higher than that in the patch and plaque stages (P <0.05). There was no significant correlation between the expression of STIM1 and ethnicity, gender, age, human herpesvirus 8 (HHV-8) infection, human immunodeficiency virus (HIV) infection, lesion area and so on (P> 0.05). There was no significant difference in the expression of STIM1 protein among HIV-positive patients with HHV-8 double positive and HIV-negative patients with HHV-8 negative (P> 0.05). Conclusions The expression of STIM1 in the Kaposi’s sarcoma is higher than that in the patch and plaque stage, which may play an important role in the progression of Kaposi’s sarcoma.