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创伤是导致人类死亡的重要因素,我国每年死于创伤的人数达70余万人,其中50%合并创伤失血性休克(traumatic hemorrhagic shock,THS)。机体免疫功能与创伤的治疗及预后密切相关。有效的液体复苏在恢复机体循环血量、维持血压、保障组织和器官的循环关注、延缓休克进展中具有重要意义。近年来,有关不同液体复苏方式及不同类型复苏液在THS早期治疗中的作用及其对免疫功能的影响研究取得了一些进展。本文就THS后机体免疫系统的改变,非限制性液体复苏与限制性液体复苏,不同复苏液在THS早期治疗中的作用及对机体免疫功能的影响作一综述。
Trauma is an important factor leading to human deaths. The number of people who die from trauma in China reaches more than 700,000 each year, of which 50% have traumatic hemorrhagic shock (THS). Immune function is closely related to the treatment and prognosis of trauma. Effective liquid resuscitation in the recovery of the body’s circulating blood volume, maintain blood pressure, protect the circulation of tissue and organs, delay the progress of shock is of great significance. In recent years, some researches on the effects of different fluid resuscitation methods and different types of resuscitation fluids on the early treatment of THS and their effects on immune function have been made. This article reviews the changes of the immune system after THS, the role of nonrestrictive fluid resuscitation and limited fluid resuscitation, the effect of different resuscitation fluid on the early treatment of THS, and the impact on immune function.