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目的探讨侵袭性脑膜瘤的临床病理特点及其对治疗和预后的影响。方法集７例以癫痫为首发症状，并经病理证实对瘤周脑组织有侵犯的手术切除标本，行临床病理对比观察分析，并以１５例非侵袭性良性脑膜瘤之相同观察作对照。结果侵袭性与非侵袭性脑膜瘤，在组织学分类和细胞形态上看不出明显差别，也无肯定的恶性证据，但其生物学行为不同。前者以条索状侵入脑实质，“分割”或“包绕”脑组织呈岛状或半岛状，使脑组织发生神经细胞变性和脱髓鞘等改变，虽然其瘤体明显小于对照组，但其造成的上述损害则明显重于对照组。结论侵袭性脑膜瘤细胞形态良性，但生物学行为呈恶性倾向，并对脑组织造成较重损害，当属恶性范畴；脑侵犯可作为判断良恶性、术后复发和预后估计，以及确定手术范围的重要指标；易引发癫痫，可能是局部脑组织受损，网络重建“短路”形成等之结果。
Objective To investigate the clinicopathological characteristics of invasive meningioma and its impact on the treatment and prognosis. Methods Seven cases with epilepsy as the first symptom and confirmed by pathological invasion of the peritumor brain tissue were resected and observed clinically and pathologically. Fifteen non-invasive benign meningiomas were used as controls. The results of invasive and non-invasive meningioma, histological classification and cell morphology showed no significant difference, there is no certain evidence of malignancy, but its biological behavior is different. The former invades the brain parenchyma by the cord-like shape. The brain tissue of the “split” or “wrap around” is island or peninsula-like shape, which causes degeneration and demyelination of the nerve cells in the brain tissue. Although the tumor size is obviously smaller than that of the control group, The damage caused by it is obviously heavier than the control group. Conclusions Invasive meningioma cells are benign, but their biological behavior is malignant and cause severe damage to brain tissue. It is a malignant category. Brain invasion can be used as a guide to evaluate benign and malignant, postoperative recurrence and prognosis, and determine the scope of the operation Of the important indicators; easily lead to epilepsy, may be impaired local brain tissue, network reconstruction “short circuit” the formation of the result.