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本文介绍了我院1987～1993年对接触固体推进剂组分过氯酸铵粉尘作业工人80余人次的X线动态观察。肺功能检查及血气分析等。现已发现6例接触过氯酸铵工人在X线检查中肺部有明显的广泛肺间质纤维化改变,其中7例已有纤维化前期改变,两项检出率为61.90％,与对照组比较有极显著差异(P<0.01)。肺功能检查有8例已有不同程度的通气功能、小气道功能及弥散功能障碍,检出率为38.0％,在多年的临床观察中,还发现这些病理改变有进行性发展趋势。由于过氨酸铵粉尘是一种能溶于水的化合物,其水溶液pH为4～5,目前引起接触人员肺间质纤维化的病理过程尚无肯定结论。本文对过氯酸铵粉尘所致的肺间质纤维化变的原因进行了初步讨论。
This article describes the 1987 to 1993 in our hospital on solid propellant components of ammonium perchlorate dust workers more than 80 times the X-ray dynamic observation. Pulmonary function tests and blood gas analysis. Six patients exposed to ammonium perchlorate have been found to have significantly extensive pulmonary fibrosis changes in the lungs during the X-ray examination. Seven of these patients had pre-fibrotic changes with two detected rates of 61.90% There were significant differences (P <0.01). There are 8 cases of pulmonary function tests have different degrees of ventilation, small airway function and diffuse dysfunction, the detection rate was 38.0%, in many years of clinical observation, also found that these pathological changes have progressive development trend. As ammonium perchlorate dust is a water-soluble compound, the pH of its aqueous solution is 4 to 5, the pathological processes that cause exposure to interstitial fibrosis in humans are not yet conclusive. This paper discussed the causes of pulmonary fibrosis caused by ammonium perchlorate dust.