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目的分析合并乙肝病毒感染的结核病患者发生药物性肝炎的临床情况。方法对182例合并乙肝的结核病患者抗结核治疗中的肝功能情况进行回顾性分析。结果两重感染的患者中抗结核药物诱导肝损害的发生率为27.5%。34例(68%)发生在前3个月内。8例患者出现相关肝炎症状,其中纳差、恶心、呕吐症状最常见。16例(32%)需要停药或修改方案,34例(68%)患者经过积极治疗肝功能正常或好转。结论合并乙肝的结核病患者更易发生药物性肝炎。
Objective To analyze the clinical situation of drug-induced hepatitis in tuberculosis patients with hepatitis B virus infection. Methods A retrospective analysis was performed on the liver function of 182 TB patients with hepatitis B during anti-TB treatment. Results The incidence of liver damage induced by antituberculosis drugs in patients with dual infection was 27.5%. 34 cases (68%) occurred within the first 3 months. Eight patients had related hepatitis symptoms, of which the most common symptoms of anorexia, nausea and vomiting. Twenty-six patients (32%) required discontinuation or modification and 34 (68%) had active treatment of normal or improved liver function. Conclusion Hepatitis B patients with hepatitis B are more likely to develop drug-induced hepatitis.