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目的研究局灶性脑缺血大鼠脑皮层中强啡肽A(1-13)的经时表达及脑含水量的变化。方法用线栓法建立大鼠大脑中动脉梗塞模型,用免疫组织化学方法观察脑缺血组大鼠及假手术对照组大鼠缺血侧及非缺血侧脑皮层强啡肽A(1-13)在脑缺血100 min后再灌注4、8、24 h的表达及脑含水量的变化。结果假手术对照组大鼠缺血侧及非缺血侧脑皮层表达强啡肽A(1-13)的细胞数分别是每高倍镜视野(60.2±5.1)个及(61.1±3.9)个,在脑缺血后再灌注4、82、4 h大鼠缺血侧及非缺血侧脑皮层的强啡肽A(1-13)表达细胞数分别是每高倍镜视野(39.3±6.2)个及(60.3±3.7)个、(41.5±5.8)个及(60.1±3.9)个、(25.2±5.1)个及(59.6±5.9)个;而脑缺血后再灌注4、8、24 h的缺血侧含水量逐渐增加。结论大鼠脑缺血后缺血侧脑皮层的强啡肽A(1-13)表达逐渐减少而含水量逐渐增加。
Objective To investigate the temporal expressions of dynorphin A (1-13) and changes of brain water content in focal cerebral ischemia rats. Methods The model of middle cerebral artery occlusion (MCAO) was established by thread occlusion in rats. Immunohistochemistry was used to observe the changes of dynorphin A (1- 13) after cerebral ischemia 100 min reperfusion 4,8,24 h expression and changes in brain water content. Results The number of cells expressing dynorphin A (1-13) in the ischemic and nonischemic cortex in the sham-operation control group was 60.2 ± 5.1 and 61.1 ± 3.9 respectively, The number of dynorphin A (1-13) expressing cells in ischemic and non-ischemic cortex at 4, 82, and 4 h after cerebral ischemia was 39.3 ± 6.2 And (60.3 ± 3.7), (41.5 ± 5.8) and (60.1 ± 3.9), (25.2 ± 5.1) and (59.6 ± 5.9), respectively Ischemic water content increased gradually. Conclusion The expression of droperidol A (1-13) in ischemic cortex gradually decreases and the water content gradually increases after cerebral ischemia in rats.