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克服肿瘤细胞的耐药性是化疗需要解决的重大课题。本项目通过分析20株中国人肿瘤细胞中 O~6-甲基鸟嘌呤-DNA-甲基转移酶(简写 MGMT)的活性与对烷化剂亚硝脲耐药性的关系的实验;通过使用亚硝脲药物治疗移植高和低MGMT 肿瘤细胞的荷瘤裸鼠实验;通过向对烷化剂亚硝脲敏感、耐药的细胞分别转导 MGMT cDNA 以及 MGMT 反义 RNA的实验;证明肿瘤细胞中的 MGMT 水平决定了细胞对烷化
To overcome the drug resistance of tumor cells is a major issue to be solved in chemotherapy. This project through the analysis of 20 Chinese cancer cells in the O ~ 6-methylguanine-DNA-methyltransferase (abbreviation MGMT) activity and alkylating agent nitrous oxide resistance experiment; by using Nitrosourea drug treatment of high and low MGMT tumor cells transplanted in nude mice experiments; by sensitive to the alkylating agent nitrosourea, resistant cells were transduced MGMT cDNA and MGMT antisense RNA experiments; that the tumor cells The level of MGMT in cells determines the alkylation of cells