O-Lauroyl chitosan/poly(L-lactide) (OCS/PLLA) blend membranes with different compositions were prepared by solutioncasting approach using chloroform as common solvent. The experimental results of FT-IR, DSC and WAXD indicated that interassociation hydrogen-bond interactions existed between OCS and PLLA in the blend membranes. And SEM observation confirmed that the blend membranes with suitable compositions were compatible.