Castleman病于1956年Castleman等~([1])首次描述并报道,又称血管滤泡性淋巴组织增生或巨大淋巴结增生症,病因尚不明确,临床较少见。Td T全称是末端脱氧核苷酸转移酶,其主要在胸腺皮质细胞和少数骨髓淋巴细胞表达,在淋巴结及脾等成熟淋巴细胞中不表达,在T淋巴母细胞淋巴瘤中阳性率较高。然而,很多淋巴组织增生性疾病也有不同程度的Td T阳性的淋巴母细胞增生、表达;也有报道 Castleman’s disease was first described and reported by Castleman et al ~ ([1]) in 1956. The etiology of the Castleman’s disease, also known as follicular lymphoid hyperplasia or giant lymph node hyperplasia, is unknown and clinically rare. The full name of Td T is terminal deoxynucleotidyl transferase, which is mainly expressed in thymus cortical cells and a few myeloid lymphocytes, but not in mature lymphocytes such as lymph nodes and spleen, and has a high positive rate in T lymphoblastic lymphoma. However, many lymphoproliferative diseases also have varying degrees of Td T-positive lymphoblastic proliferation and expression; it has also been reported