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目的调查宝鸡地区0~7岁儿童血清25(OH)D水平,为0~7岁儿童合理摄入及补充维生素D提供科学依据。方法选用2011年1月-2014年6月来宝鸡市第二人民医院儿童保健科体检儿童1 874例。其中男1 005例,女869例,采用国际先进的高效液相色谱-串联质谱法测定所有研究对象的血清25(OH)D水平。结果 1)宝鸡市0~7岁儿童血清25(OH)D均值为(21.02±13.27)ng/ml,996例(53.15%)存在血清25(OH)D缺乏,390例(20.81%)存在血清25(OH)D不足,0月~组最低,3岁~组最高。2)市区(金台、渭滨)、陈仓区、周边县区、外地血清25(OH)D水平依次递增。3)夏季和秋季的血清25(OH)D水平显著高于春季和冬季,且夏、秋季儿童血清25(OH)D缺乏、不足率显著低于春、冬季。4)超重与非超重儿童血清25(OH)D分别为(24.67±10.61)ng/ml和(20.11±11.57)ng/ml,而肥胖与非肥胖儿童血清25(OH)D分别为(25.37±10.25)ng/ml和(20.56±10.74)ng/ml,组间血清25(OH)D差异均有统计学意义。5)不同性别血清25(OH)D差异无统计学意义。结论宝鸡市0~7岁儿童血清25(OH)D普遍缺乏,应采取积极、有效的措施加强0~7岁儿童维生素D的摄入和补充。
Objective To investigate the level of serum 25 (OH) D in children aged 0-7 years in Baoji region and provide a scientific basis for rational intake and vitamin D supplementation in children aged 0-7 years. Methods From January 2011 to June 2014, 1874 children were screened for the Children’s Health Branch of Second People’s Hospital of Baoji City. Among them, there were 1 005 males and 869 females, and the serum 25 (OH) D levels of all the subjects were measured by the internationally advanced high performance liquid chromatography-tandem mass spectrometry. Results The mean serum 25 (OH) D in children aged 0-7 years in Baoji City was (21.02 ± 13.27) ng / ml, there was a lack of 25 (OH) D in 996 cases (53.15%), and serum 25 (OH) D is not enough, the lowest in group 0 ~ the highest in group 3 ~ age group. 2) The levels of serum 25 (OH) D in the urban areas (Jintai, Weibin), Chencang, surrounding counties and other places increased successively. 3) The levels of serum 25 (OH) D in summer and autumn were significantly higher than those in spring and winter, and the serum 25 (OH) D deficient in summer and autumn was significantly lower than that in spring and winter. Serum 25 (OH) D was (24.67 ± 10.61) ng / ml and (20.11 ± 11.57) ng / ml respectively in overweight and non-overweight children, while the serum 25 (OH) D in obese and non-obese children was (25.37 ± 10.25) ng / ml and (20.56 ± 10.74) ng / ml, respectively. The differences of serum 25 (OH) D between the two groups were statistically significant. 5) There was no significant difference in serum 25 (OH) D between different sexes. Conclusion Serum 25 (OH) D in children aged 0-7 years in Baoji is generally lacking. Active and effective measures should be taken to strengthen the intake and supplement of vitamin D in children aged 0-7 years.