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复发性口腔阿弗它的治疗,到目前为止仍较困难,多数药对此病无满意疗效,最重要的是不能防止复发。作者用酞胺哌啶酮治疗口腔阿弗它40例,取得良好效果,今分析如下。接受酞胺哌啶酮(thalidomide)治疗的40例中,19例患严重的口腔阿弗它,17例为轻型,3例患有口、生殖器阿弗它,1例有萨顿和萨顿氏复发性坏死性粘膜腺周围炎。患者年龄从7岁到80岁,女性21人,男性19人。病程2月至40年。初诊时对患者进行全面检查,包括实验室检查,治疗时亦记录副作用,根据临床表现与相应的组织学检查来确定诊断。严重的阿弗它患者,最初剂量为300mg/日,在1～3个月内逐减为100mg/日,中等程度的患者开始给100mg/日,以后在1～3月内减为50mg/日,21位口腔阿弗它患者服安慰剂。
Recurrent oral aphthous its treatment, so far still more difficult, the majority of drugs are not satisfied with the efficacy of this disease, the most important thing is not to prevent recurrence. The authors used thalidomide treatment of oral aphthous it 40 cases, achieved good results, the following analysis. Of the 40 patients treated with thalidomide, 19 had severe oral aphthous, 17 were light, 3 had oral and genital aphthous, and 1 had Sutton and Sutton Recurrent necrotic mucosal gland inflammation. Patients ranged in age from 7 to 80 years, 21 were women and 19 were males. Duration of 2 months to 40 years. The first visit to a comprehensive examination of patients, including laboratory tests, treatment side effects are also recorded, according to the clinical manifestations and the corresponding histological examination to determine the diagnosis. Serious aphthous patients, the initial dose of 300mg / day, within 1 to 3 months reduced to 100mg / day, medium-level patients began to give 100mg / day, after 1 to 3 months reduced to 50mg / day 21 oral alfa patients took placebo.