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目的：探讨盆底肌锻炼联合度洛西汀治疗女性压力性尿失禁的临床疗效和安全性。方法将80例女性压力性尿失禁患者随机分为两组，每组40例，均予以盆底肌锻炼治疗，研究组在此基础上联合度洛西汀治疗，观察8周。采用尿垫试验和尿失禁自我等级评价评定临床疗效。结果治疗8周末，研究组治愈率为86．8％、总有效率为100％，对照组分别为54．1％、70．3％，研究组显著高于对照组（ P＜0．01）；两组尿失禁量及尿失禁自我等级评价评分均较治疗前显著下降（P＜0．01），研究组较对照组下降更显著（P＜0．01）。研究组偶见轻度头晕、头痛、口干等，且患者可耐受。结论盆底肌锻炼联合度洛西汀治疗女性压力性尿失禁疗效显著，优于单用盆底肌锻炼治疗，值得临床推广应用。“,”Objective To explore the efficacy and safety of pelvic floor muscle ex‐ercise (PFME) plus duloxetine in the treatment of female stress urinary incontinence (SUI) .Methods Eighty female SUI patients were randomly assigned to two groups of 40 ones each ,both groups received PFME ,and on this basis research group was plus duloxetine for 8 weeks .Efficacies were assessed with pad test and ICI2Q .Results At the end of the 8th week cure and total effective rate were respectively 86 .8% and 100% in research group and 54 .1% and 70 .3% in control group ,the former were significantly higher than the latter (P<0 .01);urinary incontinence quantity and the ICI2Q scores of both groups low‐ered more significantly compared with pretreatment (P< 0 .01) ,so did those in research than control group (P<0 .01) .Mild dizziness ,headache and dry mouth etc .emerged occasionally in research group and were tolerable .Conclusion PFME plus duloxetine has an evident effect compared with single PFME in female SUI and is worth clinical generalization and application .