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背景 3-5％的亚洲人或非洲人缺乏血小板CD36(糖蛋白[GP]Ⅳ)。这类人有引起CD36免疫的危险,但发生的数量和其在输血医学中的重要性还不清楚。研究设计及方法 报道了4例CD36 一母亲生产的5例新生儿血小板减少症婴儿的临床和实验室情况,对3位母亲作了CD36基因测序。文献综述CD36同种免疫。结果用正常血小板和对应患儿父亲血小板作4名母亲CD36同种抗体反应检测。2名非洲-美洲母亲CD36基因是纯合子1264T>G突变,1名意大利血统母亲确定为既往尚未
Background 3-5% of Asians or Africans lack platelet CD36 (glycoprotein [GP] Ⅳ). Such humans are at risk of eliciting CD36 immunity, but the magnitude of their occurrence and their importance in transfusion medicine are unclear. Study Design and Methods Reported the clinical and laboratory conditions of 4 neonates with thrombocytopenia in 5 neonates with CD36-1 mothers and CD36 gene sequencing of 3 mothers. Literature review CD36 Alloimmunity. The results of normal platelets and the corresponding pediatric platelet father for the four mothers CD36 allotype antibody test. Two African-American mothers CD36 gene is homozygous 1264T> G mutation, one Italian descent mother identified as not yet