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目的 了解有冠心病 (CHD)家族史儿童临床特点。方法 对 83例有冠心病家族史的儿童进行临床资料、超重及肥胖发生率、血压、血脂、血糖分析。结果 83例有冠心病家族史的儿童均为学龄儿童 ,男童多见 ,以祖父母及外祖父母有CHD者多见 ,早发与非早发CHD比例为 1∶3 4。与无CHD家族史健康儿童比较 ,有CHD家族史儿童超重及肥胖发生率明显增高 ,存在明显的脂质代谢紊乱 ,血脂水平及脂质异常血症发生率明显增高 ,收缩压、舒张压及高血压检出率明显增高 (P <0 0 5 ) ,有早发CHD家族史儿童改变更为明显 ,未发现高血糖症。结论 有CHD家族史儿童与其他CHD危险因素如肥胖、脂质代谢紊乱、血压异常密切相关 ,以有早发CHD家族史儿童明显 ,成年后发生CHD的危险性可能显著增高 ,提示应尽早进行干预。
Objective To understand the clinical features of children with family history of coronary heart disease (CHD). Methods Clinical data, incidence of overweight and obesity, blood pressure, blood lipid and blood sugar in 83 children with a family history of coronary heart disease were analyzed. Results 83 cases of children with family history of coronary heart disease were all school-aged children, more common in boys, with grandparents and grandparents CHD more common, early-onset and non-early-onset CHD ratio of 1: 34. Compared with healthy children without CHD family history, children with CHD family history of overweight and obesity significantly increased the incidence of significant lipid metabolism disorders, lipid levels and lipid abnormalities were significantly higher incidence of systolic blood pressure, diastolic blood pressure and high The detection rate of blood pressure was significantly higher (P <0 05). There was more obvious change in children with premature CHD family history and no hyperglycemia was found. Conclusion Children with CHD family history and other CHD risk factors such as obesity, lipid metabolism disorder, abnormal blood pressure are closely related to the early onset of family history of CHD children was significantly increased the risk of adult CHD may be significantly increased, suggesting that early intervention .